Cuparencu B, Safta L, Sandor V, Fabian A, Horak J, Marmo E
Res Commun Chem Pathol Pharmacol. 1986 Jan;51(1):53-8.
In urethane anesthetized rats, the intracerebroventricular (icv.) microinjection of sodium glutamate or KCl induced cardiac arrhythmias. These cardiac rhythm disorders could be prevented by the icv. administration of imidazole. The i.v. injection of the same doses of imidazole elicited cardiac arrhythmias. The antiarrhythmic activity of imidazole is probably due to its ability to stimulate phosphodiesterase activity, which leads to a decrease in cGMP and/or cAMP cerebral levels.
在氨基甲酸乙酯麻醉的大鼠中，脑室内微量注射谷氨酸钠或氯化钾可诱发心律失常。这些心律失常可通过脑室内注射咪唑来预防。静脉注射相同剂量的咪唑会引发心律失常。咪唑的抗心律失常活性可能归因于其刺激磷酸二酯酶活性的能力，这会导致脑内cGMP和/或cAMP水平降低。
