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复发性自然流产夫妇中主要组织相容性复合体定位补体C4和类固醇21-羟化酶基因重排

Major histocompatibility complex located complement C4 and steroid 21-hydroxylase gene rearrangements in couples with recurrent spontaneous abortions.

作者信息

Laitinen T, Lokki M L, Partanen J, Tulppala M, Ylikorkala O, Koskimies S

机构信息

Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service, Helsinki.

出版信息

Eur J Immunogenet. 1992 Dec;19(6):413-8. doi: 10.1111/j.1744-313x.1992.tb00084.x.

DOI:10.1111/j.1744-313x.1992.tb00084.x
PMID:1362078
Abstract

Major Histocompatibility Complex (MHC) class III located complement C4 and steroid 21-hydroxylase (21OH) genes, which form various deletion and duplication units, were studied by TaqI Restriction Fragment Length Polymorphism (RFLP) in 58 Finnish couples who suffered recurrent spontaneous abortions (RSA). The gene rearrangements found in the RSA couples did not differ from those in the controls.

摘要

通过TaqI限制性片段长度多态性（RFLP）技术，对58对患有复发性自然流产（RSA）的芬兰夫妇中位于主要组织相容性复合体（MHC）III类区域的补体C4和类固醇21-羟化酶（21OH）基因进行了研究，这些基因形成了各种缺失和重复单元。在RSA夫妇中发现的基因重排与对照组并无差异。

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