ISHIZAKA K, ISHIZAKA T, CAMPBELL D H
J Exp Med. 1959 Feb 1;109(2):127-43. doi: 10.1084/jem.109.2.127.
Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), does not have the activity, whereas, Ag(3)Ab(2) and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.
在抗原过量情况下形成的可溶性牛血清白蛋白-抗牛血清白蛋白复合物，能使正常豚鼠立即产生皮肤反应。该反应机制并非被动或反向被动过敏反应。复合物本身具有毒性。复合物的皮肤活性取决于其组成。很明显，由两个抗原分子和一个抗体分子组成的复合物（Ag(2)Ab）没有活性，而Ag(3)Ab(2)及更复杂的复合物则有活性。文中还介绍了补体的作用以及对抗体-抗原复合物结构变化的推测。
