van Gool W A, Bolhuis P A
Afdeling Neurologie, Academisch Medisch Centrum, Amsterdam.
Tijdschr Gerontol Geriatr. 1992 Dec;23(6):212-6.
Studies into the value of examination of the cerebrospinal fluid (CSF) in diagnosing Alzheimer's disease are reviewed. The diagnostic utility of about 60 substances including CSF measures related to classical neurotransmitters, (neuro)peptides, proteins, amino-acids, trace elements, and constituents of senile plaques and neurofibrillary tangles is evaluated. Technical, methodological, and ethical issues relevant to this kind of studies are discussed. None of the CSF constituents studies so far, has a proven diagnostic utility. Increased knowledge concerning macromolecular changes in the brain and improved immunochemical techniques make the outlook for a diagnostic test for Alzheimer's disease on CSF promising.
本文综述了脑脊液（CSF）检查在诊断阿尔茨海默病中的价值研究。评估了约60种物质的诊断效用，这些物质包括与经典神经递质、（神经）肽、蛋白质、氨基酸、微量元素以及老年斑和神经原纤维缠结成分相关的脑脊液指标。讨论了与此类研究相关的技术、方法和伦理问题。迄今为止，尚未有脑脊液成分研究被证实具有诊断效用。随着对大脑中大分子变化的认识增加以及免疫化学技术的改进，基于脑脊液的阿尔茨海默病诊断测试前景可期。
