SANO S, INOUE S, TANABE Y, SUMIYA C, KOIKE S
Science. 1959 Jan 30;129(3344):275-6. doi: 10.1126/science.129.3344.275.
It is concluded that mitochondria are involved in three steps of porphyrin and heme biosynthesis-first, in the formation of delta-aminolevulinic acid from glycine and active succinate; second, in the synthesis of protoporphyrin; third, in the incorporation of iron into the porphyrin ring-that is, in heme formation.
得出的结论是，线粒体参与卟啉和血红素生物合成的三个步骤——首先，参与由甘氨酸和活性琥珀酸形成δ-氨基乙酰丙酸；其次，参与原卟啉的合成；第三，参与铁掺入卟啉环，即血红素的形成。
