Hochmeister M, Miescher E, Lipowec W, Borer U V, Dirnhofer R
Institut für Rechtsmedizin, Universität Bern.
Beitr Gerichtl Med. 1992;50:95-8.
Nonoxinol 9 effectively inactivates high titres of HIV in vitro, which suggest its use for reducing HIV-transmission via sexual intercourse. Therefore, the suggestion has been made for the treatment of sexual assault victims with a topical anti-HIV agent such as nonoxinol 9 as soon as possible after a sexual assault has occurred. From the forensic point of view it becomes pertinent to determine whether or not nonoxinol 9 would have an adverse effect on the high-molecular weight deoxyribonucleic acid (DNA) in vaginal swabs and thereby impact RFLP results. The study demonstrates that nonoxinol 9 does not have a negative effect on the ability to produce RFLP patterns. Therefore, the early administration of the topical anti-HIV agent nonoxinol 9 has to be considered as an important step in the medical treatment of sexual assault victims.
壬苯醇醚9在体外能有效使高滴度的HIV失活，这表明其可用于减少通过性交传播HIV。因此，有人建议在性侵犯发生后尽快用局部抗HIV药物如壬苯醇醚9对性侵犯受害者进行治疗。从法医角度来看，确定壬苯醇醚9是否会对阴道拭子中的高分子量脱氧核糖核酸（DNA）产生不利影响，从而影响限制性片段长度多态性（RFLP）结果就变得至关重要。该研究表明，壬苯醇醚9对产生RFLP图谱的能力没有负面影响。因此，早期给予局部抗HIV药物壬苯醇醚9必须被视为性侵犯受害者医学治疗中的重要一步。
