Wilson W R, Mosimann F
Department of Internal Medicine, Mayo Clinic, Rochester, MN 55901.
J Hosp Infect. 1992 Nov;22 Suppl A:3-8. doi: 10.1016/s0195-6701(05)80002-7.
The suitability of commonly used antimicrobial regimens for prophylaxis in abdominal surgery and treatment of intra-abdominal sepsis is discussed. These various therapies are often limited in their usefulness by the range of microorganisms against which they are effective and thus, to extend the antimicrobial cover, agents may be combined. Some forms of therapy may produce adverse effects in susceptible patients, thus limiting their use to certain groups, or there may be cost constraints. Beta-lactamase-inhibiting compounds appear to offer an optimal combination of a broad spectrum of activity against aerobic and anaerobic microorganisms, minimal toxicity and reasonable cost.
本文讨论了腹部手术预防和腹腔内脓毒症治疗中常用抗菌方案的适用性。这些不同的治疗方法通常因有效对抗的微生物范围有限而实用性受限，因此，为扩大抗菌覆盖范围，可能会联合使用药物。某些治疗形式可能会在易感患者中产生不良反应，从而限制其仅用于特定人群，或者可能存在成本限制。β-内酰胺酶抑制化合物似乎提供了针对需氧和厌氧微生物的广谱活性、最小毒性和合理成本的最佳组合。
