Croft N, Yap P L, Mok J Y, Hague R A, Burns S M
Regional Infectious Diseases Unit, City Hospital, Edinburgh.
Scott Med J. 1992 Oct;37(5):138-41. doi: 10.1177/003693309203700503.
There is little published data on concomitant use of zidovudine and intravenous immunoglobulin (IV IgG). In this paper we review our experience of four HIV-1 infected children treated with zidovudine for periods of 19-33 months (mean 26.5 months) subsequent to starting IV IgG for period of 18-20 months (mean 19 months). In these children the only clear benefit we found was in one child who had developed HIV encephalopathy which resolved after starting zidovudine. The respective roles of zidovudine and intravenous immunoglobulin in HIV-1 infected children need to be clarified in larger comparative trials.
关于齐多夫定与静脉注射免疫球蛋白（IV IgG）联合使用的已发表数据很少。在本文中，我们回顾了4例HIV-1感染儿童的治疗经历，这些儿童在开始静脉注射免疫球蛋白治疗18 - 20个月（平均19个月）后，接受齐多夫定治疗19 - 33个月（平均26.5个月）。在这些儿童中，我们发现的唯一明显益处是一名患有HIV脑病的儿童，在开始使用齐多夫定后病情得到缓解。齐多夫定和静脉注射免疫球蛋白在HIV-1感染儿童中的各自作用需要在更大规模的对照试验中加以明确。
