H2受体拮抗剂西咪替丁、雷尼替丁、法莫替丁和尼扎替丁对兔胃底和乙状结肠的比较研究。

Comparative study of the H2-receptor antagonists cimetidine, ranitidine, famotidine and nizatidine on the rabbit stomach fundus and sigmoid colon.

作者信息

Kounenis G, Koutsoviti-Papadopoulou M, Elezoglou A, Voutsas A

机构信息

Department of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.

出版信息

J Pharmacobiodyn. 1992 Oct;15(10):561-5. doi: 10.1248/bpb1978.15.561.

DOI:10.1248/bpb1978.15.561

PMID:1362967

Abstract

The H2-receptor antagonists, cimetidine, ranitidine, famotidine and nizatidine, were tested for their effect on the isolated smooth muscle strips from the rabbit stomach fundus and sigmoid colon. These H2-receptor antagonists were found to possess a concentration-dependent contractile effect on the above smooth muscle preparations and the order of potency was: ranitidine = nizatidine > famotidine > cimetidine. In addition, the smooth muscle preparations from the sigmoid colon were significantly more sensitive to the above compounds than the smooth muscle preparations from the stomach fundus.

摘要

对H2受体拮抗剂西咪替丁、雷尼替丁、法莫替丁和尼扎替丁进行了测试，观察它们对兔胃底和乙状结肠离体平滑肌条的作用。发现这些H2受体拮抗剂对上述平滑肌制剂具有浓度依赖性收缩作用，其效价顺序为：雷尼替丁 = 尼扎替丁 > 法莫替丁 > 西咪替丁。此外，乙状结肠的平滑肌制剂对上述化合物的敏感性明显高于胃底的平滑肌制剂。