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1
The role of pH gradient in the distribution of ammonia between blood and cerebrospinal fluid, brain and muscle.pH梯度在血液与脑脊液、脑与肌肉之间氨分布中的作用。
J Clin Invest. 1959 Feb;38(2):373-83. doi: 10.1172/JCI103811.
2
Alkaline environmental pH has no effect on ammonia excretion in the mudskipper Periophthalmodon schlosseri but inhibits ammonia excretion in the related species Boleophthalmus boddaerti.碱性环境pH值对弹涂鱼（Periophthalmodon schlosseri）的氨排泄没有影响，但会抑制相关物种大弹涂鱼（Boleophthalmus boddaerti）的氨排泄。
Physiol Biochem Zool. 2003 Mar-Apr;76(2):204-14. doi: 10.1086/374281.
3
The ability of acidic pH, growth inhibitors, and glucose to increase the proton motive force and energy spilling of amino acid-fermenting Clostridium sporogenes MD1 cultures.酸性pH值、生长抑制剂和葡萄糖增加产芽孢氨基酸发酵型梭状芽孢杆菌MD1培养物的质子动力和能量溢流的能力。
Arch Microbiol. 2005 May;183(4):236-42. doi: 10.1007/s00203-005-0765-x. Epub 2005 Mar 15.
4
Exercise-induced hyperammonemia: peripheral and central effects.运动诱发的高氨血症：外周和中枢效应。
Int J Sports Med. 1990 May;11 Suppl 2:S129-42. doi: 10.1055/s-2007-1024864.
5
The passage of ammonia across the blood-brain-barrier and its relation to blood pH.氨通过血脑屏障及其与血液pH值的关系。
J Clin Invest. 1958 Dec;37(12):1724-8. doi: 10.1172/JCI103764.
6
L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure.L-鸟氨酸-L-天冬氨酸可降低急性肝衰竭大鼠的血浆和脑脊液氨水平，并预防脑水肿。
Hepatology. 1999 Sep;30(3):636-40. doi: 10.1002/hep.510300311.
7
Time-varying migration process of moving neutralization boundary on the immobilized pH gradient strip in the weak-base rehydration buffer.固定化 pH 梯度条中弱碱复溶缓冲液中移动中和边界的时变迁移过程。
J Sep Sci. 2011 May;34(10):1212-9. doi: 10.1002/jssc.201000813. Epub 2011 Apr 15.
8
Role of glutamine in cerebral nitrogen metabolism and ammonia neurotoxicity.谷氨酰胺在脑氮代谢及氨神经毒性中的作用。
Ment Retard Dev Disabil Res Rev. 2001;7(4):280-6. doi: 10.1002/mrdd.1039.
9
Uptake of ammonia by muscle; its implications in ammoniagenic coma.肌肉对氨的摄取；其在产氨性昏迷中的意义。
N Engl J Med. 1955 Dec 29;253(26):1143-7. doi: 10.1056/NEJM195512292532602.
10
Ammonia in clinical medicine. I. Some aspects of ammonia metabolism.临床医学中的氨。I. 氨代谢的某些方面。
Folia Med Neerl. 1970;13(1):14-21.

引用本文的文献

1
The effect of acute alkalosis on renal metabolism of ammonia in cirrhotics.急性碱中毒对肝硬化患者氨肾代谢的影响。
J Clin Invest. 1962 May;41(5):1139-44. doi: 10.1172/JCI104566.
2
[INVESTIGATIONS ON THE EXCHANGE OF FREE AMINO ACIDS AND UREA BETWEEN BLOOD AND CENTRAL NERVOUS SYSTEM].[关于血液与中枢神经系统之间游离氨基酸和尿素交换的研究]
Klin Wochenschr. 1964 Jan 1;42:27-39. doi: 10.1007/BF01485676.
3
Liver and brain.肝脏和大脑。
Postgrad Med J. 1963 Apr;39(450):224-34. doi: 10.1136/pgmj.39.450.224.
4
[Respiration, acid-base equilibrium and ammonia and ammonium in the blood and cerebrospinal fluid in liver cirrhosis].[肝硬化患者血液及脑脊液中的呼吸、酸碱平衡以及氨和铵]
Klin Wochenschr. 1962 Feb 15;40:184-99. doi: 10.1007/BF02104141.
5
A comparison of certain acidbase characteristics of arterial blood, jugular venous blood and cerebrospinal fluid in man, and the effect on them of some acute and chronic acid-base disturbances.人体动脉血、颈静脉血和脑脊液某些酸碱特性的比较，以及一些急性和慢性酸碱紊乱对它们的影响。
J Physiol. 1962 Mar;160(3):381-91. doi: 10.1113/jphysiol.1962.sp006853.
6
The existence of ammonia in blood in vivo with observations on the significance of the NH4 plus minus NH3 system.体内血液中氨的存在以及对NH₄⁺-NH₃系统意义的观察。
J Clin Invest. 1960 Feb;39(2):332-41. doi: 10.1172/JCI104044.
7
[The concentration of free amino acids in the cerebrospinal fluid and its relation to the concentration of free plasma amino acids].[脑脊液中游离氨基酸的浓度及其与血浆游离氨基酸浓度的关系]
Klin Wochenschr. 1961 Aug 1;39:778-84. doi: 10.1007/BF01482094.
8
Observations on the effect of exercise on blood ammonia concentration in man.关于运动对人体血氨浓度影响的观察
Yale J Biol Med. 1960 Oct;33(2):133-44.
9
Effect of a low-carbohydrate diet on plasma and sweat ammonia concentrations during prolonged nonexhausting exercise.低碳水化合物饮食对长时间非力竭性运动期间血浆和汗液氨浓度的影响。
Eur J Appl Physiol Occup Physiol. 1995;70(1):70-4. doi: 10.1007/BF00601811.
10
Effect of ammonium chloride and urea infusions on ammonium levels and acidity of gastric juice.氯化铵和尿素输注对胃液铵水平及酸度的影响。
Gut. 1965 Aug;6(4):349-56. doi: 10.1136/gut.6.4.349.

本文引用的文献

1
Quantitative determination of glutamine and glutamic acid.谷氨酰胺和谷氨酸的定量测定。
Biochem J. 1948;43(1):51-7. doi: 10.1042/bj0430051.
2
The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma.肝脏疾病中大脑和外周对氨的摄取以及肝昏迷机制的一种假说
J Clin Invest. 1955 Apr;34(4):622-8. doi: 10.1172/JCI103111.
3
Studies in ammonia metabolism. III. The experimental production of coma by carotid arterial infusion of ammonium salts.氨代谢研究。III. 通过颈动脉输注铵盐实验性诱导昏迷
Surgery. 1958 Mar;43(3):476-85.
4
The passage of ammonia across the blood-brain-barrier and its relation to blood pH.氨通过血脑屏障及其与血液pH值的关系。
J Clin Invest. 1958 Dec;37(12):1724-8. doi: 10.1172/JCI103764.
5
Absorption of drugs from the rat small intestine.药物从大鼠小肠的吸收。
J Pharmacol Exp Ther. 1958 May;123(1):81-8.
6
The differential toxicity of ammonium salts.铵盐的差异毒性。
J Clin Invest. 1958 Apr;37(4):497-501. doi: 10.1172/JCI103630.
7
Non-ionic diffusion and the excretion of weak acids and bases.非离子扩散与弱酸和弱碱的排泄
Am J Med. 1958 May;24(5):709-29. doi: 10.1016/0002-9343(58)90376-0.
8
Ammonium uptake by the extremities and brain in hepatic coma.肝昏迷时四肢和脑部对铵的摄取
J Clin Invest. 1958 Mar;37(3):414-24. doi: 10.1172/JCI103621.
9
Ammonia intoxication during treatment of alkalosis in a patient with normal liver function.一名肝功能正常的患者在碱中毒治疗期间发生氨中毒。
Am J Med. 1957 Dec;23(6):990-4. doi: 10.1016/0002-9343(57)90308-x.
10
The distribution and excretion of phenobarbital.苯巴比妥的分布与排泄。
J Clin Invest. 1957 Aug;36(8):1217-26. doi: 10.1172/JCI103518.

The role of pH gradient in the distribution of ammonia between blood and cerebrospinal fluid, brain and muscle.

作者信息

STABENAU J R, WARREN K S, RALL D P

出版信息

J Clin Invest. 1959 Feb;38(2):373-83. doi: 10.1172/JCI103811.

DOI:10.1172/JCI103811
PMID:13631069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC293165/
Abstract
摘要