GEM 91——一种硫代磷酸反义寡核苷酸，用作治疗艾滋病的药物。 - Suppr

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超能文献

GEM 91--an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS.

作者信息

Agrawal S, Tang J Y

出版信息

Antisense Res Dev. 1992 Winter;2(4):261-6. doi: 10.1089/ard.1992.2.261.

DOI:10.1089/ard.1992.2.261

PMID:1363378

Abstract

摘要

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GEM 91--an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS.GEM 91——一种硫代磷酸反义寡核苷酸，用作治疗艾滋病的药物。

Antisense Res Dev. 1992 Winter;2(4):261-6. doi: 10.1089/ard.1992.2.261.

Still looking for the real GEM.仍在寻找真正的宝石。

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Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells.与Gag mRNA互补的硫代磷酸反义寡脱氧核苷酸可阻断1型人类免疫缺陷病毒在人外周血细胞中的复制。

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Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates.用硫代磷酸反义寡核苷酸对人类免疫缺陷病毒感染细胞进行长期治疗。

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Antiviral effect of phosphorothioate oligodeoxyribonucleotides complementary to human immunodeficiency virus.与人类免疫缺陷病毒互补的硫代磷酸寡脱氧核糖核苷酸的抗病毒作用

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Antisense oligonucleotides as therapeutic agents--is the bullet really magical?反义寡核苷酸作为治疗药物——子弹真的神奇吗？

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Significant inhibitory effects of Hybridon's antisense compound on various HIV-1 replication steps in in vitro tests.Hybridon反义化合物在体外试验中对HIV-1的各种复制步骤具有显著抑制作用。

AIDS Patient Care STDS. 1996 Dec;10(6):375-6.

Antisense has growing pains.反义技术面临发展中的困难。

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The multiple inhibitory mechanisms of GEM 91, a gag antisense phosphorothioate oligonucleotide, for human immunodeficiency virus type 1.GEM 91（一种gag反义硫代磷酸酯寡核苷酸）对1型人类免疫缺陷病毒的多种抑制机制。

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Inhibition of human immunodeficiency virus replication by cell membrane-crossing oligomers.穿膜寡聚物抑制人类免疫缺陷病毒复制。

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DNA as therapeutics; an update.作为治疗手段的DNA；最新进展

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Prospects for antisense peptide nucleic acid (PNA) therapies for HIV.抗艾滋病病毒反义肽核酸（PNA）疗法的前景。

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Construction and selection of bead-bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries designed for rapid PCR-based sequencing.用于基于PCR的快速测序的珠结合组合寡核苷酸硫代磷酸酯和二硫代磷酸酯适配体文库的构建与筛选。

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Lipid-based delivery of combinations of antisense oligodeoxynucleotides for the in vitro inhibition of HIV-1 replication.基于脂质的反义寡脱氧核苷酸组合用于体外抑制HIV-1复制的递送

AAPS PharmSci. 2001;3(1):E7. doi: 10.1208/ps030107.

Gene therapy for infectious diseases.传染病的基因治疗。

Clin Microbiol Rev. 1998 Jan;11(1):42-56. doi: 10.1128/CMR.11.1.42.

Antisense inhibition of virus infections.病毒感染的反义抑制

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A general purpose RNA-cleaving DNA enzyme.一种通用的RNA切割DNA酶。

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Triplex-forming oligonucleotides trigger conformation changes of a target hairpin sequence.三链形成寡核苷酸触发靶标发夹序列的构象变化。

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