长期给予乙醇对大鼠心脏去甲肾上腺素水平的影响。
Effects of prolonged ethanol administration on the noradrenaline levels of rat heart.
作者信息
Rossi M A, Oliveira J S
出版信息
Eur J Pharmacol. 1976 Nov;40(1):187-90. doi: 10.1016/0014-2999(76)90370-8.
The effect of prolonged administration of ethanol on the noradrenaline concentration of the heart was investigated in rats. After 4 weeks there was no difference in the catecholamine levels between control and ethanol consuming rats. After 12 and 24 weeks there was a highly significant increase in heart noradrenaline concentration in hearts of experimental rats. These findings may indicate a delay in the effect of ethanol in cardiac tissue. It is further suggested that continued exposure to high levels of catecholamine may play a role in the development of cardiomyopathy in chronic alcoholism.
研究了长期给予乙醇对大鼠心脏去甲肾上腺素浓度的影响。4周后，对照组和饮用乙醇的大鼠之间儿茶酚胺水平没有差异。12周和24周后，实验大鼠心脏中的去甲肾上腺素浓度显著升高。这些发现可能表明乙醇对心脏组织的作用存在延迟。进一步表明，持续暴露于高水平的儿茶酚胺可能在慢性酒精中毒性心肌病的发展中起作用。
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