Banerjee S P, Sharma V K
Br J Pharmacol. 1978 Apr;62(4):475-9. doi: 10.1111/j.1476-5381.1978.tb07750.x.
1 The specific [3H]-ouabain binding to microsomal fractions derived from cat heart, liver, spleen, and kidney increased significantly following chronic administration of ethanol. 2 Since ouabain binds exclusively to cell membrane (Na+ + K+)-adenosine triphosphatase ((Na+ + K+)-ATPase), these results provide evidence for an increase in number of (Na+ + K+)-ATPase macromolecules during chronic alcoholism. 3 The importance of the increase in number of (Na+ + K+)-ATPase molecules in the adaptive increase in ethanol metabolism and cardiac myopathy in chronic alcoholism is discussed.
1 长期给予乙醇后，猫心脏、肝脏、脾脏和肾脏微粒体部分的特异性[3H]-哇巴因结合显著增加。2 由于哇巴因仅与细胞膜（Na+ + K+）-腺苷三磷酸酶（（Na+ + K+）-ATPase）结合，这些结果为慢性酒精中毒期间（Na+ + K+）-ATPase大分子数量增加提供了证据。3 讨论了慢性酒精中毒中（Na+ + K+）-ATPase分子数量增加在乙醇代谢适应性增加和心肌病中的重要性。
