[3H]-哇巴因与猫外周器官的结合：乙醇的影响。
[3H]-Ouabain binding to peripheral organs of cats: effect of ethanol.
作者信息
Banerjee S P, Sharma V K
出版信息
Br J Pharmacol. 1978 Apr;62(4):475-9. doi: 10.1111/j.1476-5381.1978.tb07750.x.
Abstract
1 The specific [3H]-ouabain binding to microsomal fractions derived from cat heart, liver, spleen, and kidney increased significantly following chronic administration of ethanol. 2 Since ouabain binds exclusively to cell membrane (Na+ + K+)-adenosine triphosphatase ((Na+ + K+)-ATPase), these results provide evidence for an increase in number of (Na+ + K+)-ATPase macromolecules during chronic alcoholism. 3 The importance of the increase in number of (Na+ + K+)-ATPase molecules in the adaptive increase in ethanol metabolism and cardiac myopathy in chronic alcoholism is discussed.
摘要
1 长期给予乙醇后，猫心脏、肝脏、脾脏和肾脏微粒体部分的特异性[3H]-哇巴因结合显著增加。2 由于哇巴因仅与细胞膜（Na+ + K+）-腺苷三磷酸酶（（Na+ + K+）-ATPase）结合，这些结果为慢性酒精中毒期间（Na+ + K+）-ATPase大分子数量增加提供了证据。3 讨论了慢性酒精中毒中（Na+ + K+）-ATPase分子数量增加在乙醇代谢适应性增加和心肌病中的重要性。
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[3H]-Ouabain binding to peripheral organs of cats: effect of ethanol.[3H]-哇巴因与猫外周器官的结合：乙醇的影响。
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引用本文的文献
1
Stimulation of specific [3H]-ouabain binding to microsomal preparations from rat heart and skeletal muscle by thyroid hormones: effects of 6-hydroxydopamine.甲状腺激素对大鼠心脏和骨骼肌微粒体制剂中特异性[3H]-哇巴因结合的刺激作用：6-羟基多巴胺的影响
Br J Pharmacol. 1979 Apr;65(4):615-21. doi: 10.1111/j.1476-5381.1979.tb07872.x.
本文引用的文献
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Metabolic alterations produced in the liver by chronic ethanol administration. Changes related to energetic parameters of the cell.慢性乙醇给药对肝脏产生的代谢改变。与细胞能量参数相关的变化。
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Metabolic alterations produced in the liver by chronic ethanol administration. Increased oxidative capacity.慢性乙醇给药对肝脏产生的代谢改变。氧化能力增强。
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Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administration.影响大鼠肝脏中乙醇代谢的因素及其长期给药所产生的适应性变化。
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