生物胺和γ-氨基丁酸对小鼠组织中ATP酶活性的影响。
Effect of biogenic amines and GABA on ATPase activities in mouse tissue.
作者信息
Desaiah D, Ho I K
出版信息
Eur J Pharmacol. 1976 Dec;40(2):255-61. doi: 10.1016/0014-2999(76)90060-1.
ATPase activities were studied in brain, kidney and liver (13,000 X g pellet) fraction from the mouse. Dopamine and norepinephrine added in vitro showed a dose-dependent stimulation of Na+ and K+ activated and oligomycin sensitive Mg2+ ATPase activities in brain but not kidney and liver tissue fractions. GABA and serotonin had no effect on ATPase in brain, but inhibited oligomycin sensitive Mg2+ ATPase activities in kidney and liver. The relationship between the enhancement of ATPase activity by neurotransmitters in brain and the neuronal excitation is discussed.
对小鼠脑、肾和肝（13,000×g沉淀）部分的ATP酶活性进行了研究。体外添加多巴胺和去甲肾上腺素对脑内Na⁺和K⁺激活且对寡霉素敏感的Mg²⁺-ATP酶活性呈剂量依赖性刺激，但对肾和肝组织部分无此作用。γ-氨基丁酸（GABA）和5-羟色胺（血清素）对脑内ATP酶无影响，但抑制肾和肝内对寡霉素敏感的Mg²⁺-ATP酶活性。文中讨论了脑内神经递质对ATP酶活性增强与神经元兴奋之间的关系。
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