[The central neurophysiological and neurochemical mechanisms of vomiting (a review of the literature)].

The review contains the present-day evidence on neurophysiological and neurochemical mechanisms of functioning the central components of vomiting reflex. The main attention is concentrated on the role of some brain structures in motion sickness-induced vomiting. At the same time, the literature data casting doubt on traditional view of a necessary involvement of some brain structures in the genesis of vomiting induced by motion sickness are discussed. Also there are findings of studying an effect of physiologically active substances (classical neuromediators and regulatory peptides) at a neuronal level (silent postremal cells) with the presence of an emetic effect in them during systemic administration. The current concept of vomiting center to which role the parvicellular reticular formation of brain stem can pretend is under study.