Contrucci R B, Wilpizeski C R
Ann Otol Rhinol Laryngol. 1985 May-Jun;94(3):322-3.
The current status and implications of the neurohumoral hypothesis of motion-induced vomiting are reviewed. Data show that squirrel monkey subjects vomit only once if horizontal rotation is terminated immediately on the occurrence of the emetic response. Refractory periods for multiple vomiting episodes concurrent with continued rotation are sufficiently brief to suggest that the expected presence of the hypothetical neurochemical agent in the cerebrospinal fluid of the fourth ventricle should continue to evoke more than one vomiting response even after cessation of motion stimulation. In its present form, the hypothesis is conceptually vague and should be developed further to account for a mechanism by which the expected recurrent emesis is inhibited during the period when the alleged agent is a potentially effective stimulant.
本文综述了运动诱发性呕吐的神经体液假说的现状及意义。数据显示，如果在催吐反应出现时立即停止水平旋转，松鼠猴受试者只会呕吐一次。与持续旋转同时发生的多次呕吐发作的不应期足够短暂，这表明即使在运动刺激停止后，第四脑室脑脊液中预期存在的假设性神经化学物质仍应继续引发不止一次呕吐反应。就其目前的形式而言，该假说在概念上含糊不清，应进一步完善，以解释在所谓的介质是潜在有效刺激物的期间预期的反复呕吐是如何被抑制的机制。
