Basdevant A
Service de Médecine et Nutrition, Hôtel-Dieu, Paris, France.
Diabete Metab. 1992 Nov-Dec;18(6):431-7.
A number of monoamines and neuropeptides are involved in the control of eating behavior. In the central nervous system, the medial and lateral hypothalamus (connected with cortical and limbic systems as well as with the peripheral endocrine and autonomic nervous systems) integrates informations concerning the nutritional and biopsychological status and control feeding behavior and weight regulation. Modern neurobiological techniques have generated a great range of information on the role of monoamines and neuropeptides in controlling food intake. Substances such as norepinephrine, opioids, neuropeptide Y are potent stimulators of investive behavior. Serotonin, cholecystokinin, and corticotropin-releasing factor inhibit food intake. The physiological influence of these substances is undergoing evaluation.
许多单胺和神经肽参与进食行为的控制。在中枢神经系统中,下丘脑内侧和外侧(与皮质和边缘系统以及外周内分泌和自主神经系统相连)整合有关营养和生物心理状态的信息,并控制进食行为和体重调节。现代神经生物学技术已经产生了大量关于单胺和神经肽在控制食物摄入中作用的信息。去甲肾上腺素、阿片类物质、神经肽Y等物质是摄食行为的强效刺激剂。血清素、胆囊收缩素和促肾上腺皮质激素释放因子抑制食物摄入。这些物质的生理影响正在评估中。