Danysz W, Kostowski W
Zakładu Farmakologii i Fizjologii Układu Nerwowego Instytutu Psychiatrii i Neurologii, Warszawie.
Psychiatr Pol. 1992 Sep-Oct;26(5):365-72.
The authors discuss psychotropic effects of phencyclidine (PCP) in the context of neurochemical mechanisms of schizophrenia. They concentrate on sigma receptors and PCP receptors and tie their activity with the dopaminergic system. The authors describe neuroleptic effects on sigma receptors and the therapeutic consequences. They include that the question whether the interaction of neuroleptics with sigma receptors results in therapeutic effects or rather in undesirable symptoms will decide about the future direction of treatment of schizophrenia.
作者在精神分裂症的神经化学机制背景下讨论了苯环己哌啶（PCP）的精神药物效应。他们专注于σ受体和PCP受体，并将它们的活性与多巴胺能系统联系起来。作者描述了抗精神病药物对σ受体的作用及其治疗效果。他们指出，抗精神病药物与σ受体的相互作用是产生治疗效果还是导致不良症状，这一问题将决定精神分裂症未来的治疗方向。
