Wiczkowski A, Dyla L, Sawaryn T
I Klinika Chorób Zakaźnych Sl. A. M., Bytomiu.
Przegl Lek. 1992;49(8):265-8.
The examination of 5-cholestasis indicating enzymes was carried out in patients with viral B hepatitis. The changes in activity of such enzymes: alkaline phosphatase, its liver isoenzyme, gamma glutamyltranspeptidase, 5'nucleotidase, leucine aminopeptidase and alanine aminopeptidase were estimated as for being useful in discovering the states of cholestasis. Already in the first week of observation all examined enzymes showed the highest level of activity, only in the case of FZ and FW, however the difference between the patients with and without cholestasis were markedly static. In the following weeks the differences in average activities between group with and without cholestasis were present in the case of 5'N and LAP. The activity of GGTP and AAP were high in both groups of patients. And so alkaline phosphatase is the enzyme which discovers the states of cholestasis in viral B hepatitis quickly and markedly.
对乙型病毒性肝炎患者进行了5种胆汁淤积指示酶的检测。对这些酶的活性变化：碱性磷酸酶及其肝脏同工酶、γ-谷氨酰转肽酶、5'-核苷酸酶、亮氨酸氨肽酶和丙氨酸氨肽酶进行了评估，认为它们有助于发现胆汁淤积状态。在观察的第一周，所有检测的酶就显示出最高活性水平，仅在FZ和FW的情况下如此，然而，有胆汁淤积和无胆汁淤积患者之间的差异明显无变化。在接下来的几周里，5'-核苷酸酶和亮氨酸氨肽酶在有胆汁淤积组和无胆汁淤积组之间的平均活性存在差异。两组患者的γ-谷氨酰转肽酶和丙氨酸氨肽酶活性都很高。因此，碱性磷酸酶是能快速且显著发现乙型病毒性肝炎中胆汁淤积状态的酶。
