Tímár J, Knoll B, Knoll J
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Acta Physiol Hung. 1992;79(2):131-7.
Central effects of high dose (-)deprenyl (50-100 mg/kg sc) was compared to that of (+)deprenyl and (+/-)amphetamine (AM). (+)Deprenyl and AM induced stereotyped behaviour, increased spontaneous motility in smaller and decreased it in higher doses, inhibited escape behaviour and shuttle-box avoidance. (-)Deprenyl failed to possess any of these effects, providing further evidence that AM-type metabolites have no share in the action of (-)deprenyl.
将高剂量（-）司来吉兰（50 - 100毫克/千克，皮下注射）的中枢效应与（+）司来吉兰和（+/-）苯丙胺（AM）的中枢效应进行了比较。（+）司来吉兰和AM诱导刻板行为，低剂量时增加自发活动，高剂量时减少自发活动，抑制逃避行为和穿梭箱回避反应。（-）司来吉兰没有这些效应中的任何一种，这进一步证明AM型代谢产物在（-）司来吉兰的作用中没有参与。
