Timár J, Gyarmati Z, Barna L, Knoll B
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Physiol Behav. 1996 Aug;60(2):581-7. doi: 10.1016/s0031-9384(96)80035-7.
Effects of deprenyl and amphetamine enantiomers on different behavioural patterns were compared. Whereas (+)-amphetamine in doses of 1-3 mg/kg SC, (-)-amphetamine, and (+)-deprenyl in doses of 5-20 mg/kg SC increased the locomotor activity and the time the animals displayed stereotyped head movement, enhanced the acquisition of conditioned avoidance responses, and developed positive place preference conditioning, (-)-deprenyl, even in as high a dose as 20 mg/kg SC, failed to show any amphetamine-type behavioural effect. The results provide further proof why (-)-deprenyl, in contrast to other members of the amphetamine family, can be considered as a safe drug.
比较了司来吉兰和苯丙胺对映体对不同行为模式的影响。剂量为1-3mg/kg皮下注射的（+）-苯丙胺、（-）-苯丙胺以及剂量为5-20mg/kg皮下注射的（+）-司来吉兰，均可增加动物的自发活动及出现刻板头部运动的时间，增强条件性回避反应的习得，并形成阳性位置偏爱条件反射，而（-）-司来吉兰即使在高达20mg/kg皮下注射的剂量下，也未表现出任何苯丙胺类行为效应。这些结果进一步证明了为什么与苯丙胺家族的其他成员相比，（-）-司来吉兰可被视为一种安全药物。
