Martí A, de Kolster C C, Kolster J
Departamento de Medicina, Universidad de Carabobo.
G E N. 1992 Jan-Mar;46(1):4-9.
We prospectively reviewed clinical charts of 100 consecutive patients that were admitted during the first trimester 1991 to the Emergency Department of a general hospital in order to determine the more frequent prescribed drugs and their interactions using a computer program (Drug Interaction Program), emphasizing in those drugs used to treat peptic ulcers. Number of drugs prescribed to each patient was 4.20 +/- 1.39. Antacids (39%) and cimetidine (35%) occupied the third and fourth place. There were interactions in 79 patients and in 66 of them (84%) they were important. Antacid and cimetidine were similarly prescribed, but of 35 patients who received cimetidine only 3 (8.5%) had a primary indication for its use (Gastrointestinal bleeding). Significant clinical interactions of cimetidine with other medications are analyzed. Our results indicate that drug interactions are a permanent risk in our hospitals. We suggest to use a computer program on drug interactions or an updated chart of medications in the emergency rooms of our hospitals.
我们前瞻性地回顾了1991年孕早期连续100例入住一家综合医院急诊科患者的临床病历，以便使用计算机程序（药物相互作用程序）确定更常用的处方药物及其相互作用，重点关注用于治疗消化性溃疡的药物。每位患者的处方药物数量为4.20±1.39。抗酸剂（39%）和西咪替丁（35%）分别位列第三和第四。79例患者存在药物相互作用，其中66例（84%）的相互作用较为重要。抗酸剂和西咪替丁的处方情况相似，但在35例接受西咪替丁治疗的患者中，仅有3例（8.5%）有使用该药的主要指征（胃肠道出血）。分析了西咪替丁与其他药物之间显著的临床相互作用。我们的结果表明，药物相互作用在我们医院始终是一种风险。我们建议在我院急诊科使用药物相互作用计算机程序或更新的药物图表。
