一项关于绵羊对用不同灭活剂和佐剂制备的“O”型口蹄疫病毒疫苗免疫反应的研究。
A study on the immune response of sheep to foot and mouth disease virus vaccine type 'O' prepared with different inactivants and adjuvants.
作者信息
Nair S P, Sen A K
机构信息
Indian Veterinary Research Institute Hebbal, Bangalore.
出版信息
Acta Virol. 1992 Oct;36(5):473-8.
Foot and mouth disease virus (FMDV) type 'O' was inactivated either with formaldehyde or binaryethyleneimine (BEI). Vaccines were prepared with inactivated virus incorporating aluminum hydroxide gel or mineral oil as an adjuvant. The antibody response in sheep was monitored by serum neutralization and ELISA test for a period of six months. Significant difference in antibody response was not observed between vaccines inactivated with formaldehyde or BEI. On the other hand significant difference in the antibody response was noticed between alhydrogel and oil vaccines. The high titer of antibodies stimulated by oil adjuvant vaccines persisted longer than those of alhydrogel vaccines within the period of study.
“O”型口蹄疫病毒（FMDV）用甲醛或双乙烯亚胺（BEI）进行灭活。用掺入氢氧化铝凝胶或矿物油作为佐剂的灭活病毒制备疫苗。通过血清中和试验和ELISA试验监测绵羊六个月内的抗体反应。甲醛或BEI灭活的疫苗之间未观察到抗体反应的显著差异。另一方面，水合氢氧化铝疫苗和油佐剂疫苗之间的抗体反应存在显著差异。在研究期间，油佐剂疫苗刺激产生的高滴度抗体比水合氢氧化铝疫苗刺激产生的抗体持续时间更长。
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