Brutschin P, Vock P, Fuchs W A
Rofo. 1976 Oct;125(4):365-71. doi: 10.1055/s-0029-1230480.
The hemodynamic changes during intravenous urography were studied in 120 non-selected patients (60 patients with bolus injection, 60 with infusion: 30 of each group with methylglucamine ioxitalamate, while the other 30 with sodium methylglucamine diatrizoate). There was a uniform statistically significant increase in heart rate (p less than 10(-9) as well as in cardiac output (p less than 10(-9)) (measured by means of a non-invasive impedance method). The observed changes were more marked following bolus injection than infusion. With the application of methylglucamine ioxitalamate the increase in heart rate, but not in cardiac output, was significantly less (p less than 0,01) than with that of sodium methylglucamine diatrizoate.
对120例未经挑选的患者（60例采用推注法，60例采用滴注法：每组30例使用碘他拉葡胺，另外30例使用泛影葡胺）进行静脉尿路造影期间的血流动力学变化研究。心率（p<10⁻⁹）以及心输出量（p<10⁻⁹）（采用无创阻抗法测量）均有统计学意义的一致升高。推注后观察到的变化比滴注时更明显。使用碘他拉葡胺时，心率的升高显著低于泛影葡胺（p<0.01），但心输出量无此差异。
