脱氧腺苷对干扰素诱导的抗病毒状态的可逆抑制作用。
Reversible inhibition of interferon-induced antiviral state by deoxyadenosine.
作者信息
Matsuno T, Shirasawa N, Kohno S
出版信息
Acta Virol. 1976 Dec;20(6):466-71.
PMID:13641
Abstract
Deoxyadenosine reversibly inhibited the development of antiviral state (AVS) in chick embryo fibroblasts stimulated by interferon. Studies on cellular macromolecular syntheses in deoxyadenosine-treated cells suggested that the inhibition was related to nucleolar RNA synthesis. Reference experiments with actinomycin D and cordycepin (3'deoxyadenosine) also implied causal- or interrelation between AVS development and nucleolar RNA synthesis.
摘要
脱氧腺苷可逆转干扰素刺激的鸡胚成纤维细胞中抗病毒状态（AVS）的发展。对脱氧腺苷处理的细胞中细胞大分子合成的研究表明，这种抑制与核仁RNA合成有关。放线菌素D和虫草素（3'-脱氧腺苷）的对照实验也暗示了AVS发展与核仁RNA合成之间的因果关系或相互关系。
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