Morimoto K, Tsuji K, Osawa R, Takahashi A
Eisei Shikenjo Hokoku. 1990(108):125-8.
The alkaline elution assay were applied for testing DNA damage of forestomach squamous epithelium in male F344 rat after oral administration of ethyl acrylate (EA), a forestomach carcinogen. The animals were starved for 18 hr and then given a single oral dose of EA. No DNA damage were observed by EA at the concentration of 0.1-4.0%. The weights of the forestomach increased with EA dose, reflecting edema and inflammation, but that of glandular stomach did not change with its dose.
采用碱性洗脱法检测前胃致癌物丙烯酸乙酯（EA）经口给予雄性F344大鼠后前胃鳞状上皮的DNA损伤情况。动物禁食18小时后，经口给予单次剂量的EA。在0.1 - 4.0%的浓度下，未观察到EA导致的DNA损伤。前胃重量随EA剂量增加，反映出水肿和炎症，但腺胃重量不随其剂量变化。
