Miyazaki T, Komuro T, Yomota C, Okada S
Eisei Shikenjo Hokoku. 1990(108):95-7.
Application of chitosan, a deacetylated compound of chitin obtained from shells of shrimps, was investigated with reference to the pharmaceutical excipient for directly compressed tablets. Several drugs were chosen as model compounds and their in vitro dissolution tests were carried out according to the JP XI dissolution test. When chitosan was used alone as an excipient, immediate-release tablets were obtained, as already reported. But when more than 5% of sodium alginate, 1000 cps, was added as excipient, tablets showed an extended-release property under the present experimental conditions.
对壳聚糖（一种从虾壳中获得的几丁质脱乙酰化化合物）作为直接压片用药物赋形剂的应用进行了研究。选择了几种药物作为模型化合物，并根据日本药局方第11版溶出度试验进行了体外溶出试验。如先前报道的那样，当单独使用壳聚糖作为赋形剂时，可制得速释片。但是，当添加超过5%的海藻酸钠（1000厘泊）作为赋形剂时，在当前实验条件下片剂呈现出缓释特性。
