Shigekawa M, Pearl L J
J Biol Chem. 1976 Nov 25;251(22):6947-52.
The rates of calcium transport and Ca2+-dependent ATP hydrolysis by rabbit skeletal muscle sarcoplasmic reticulum were stimulated by monovalent cations. The rate of decomposition of phosphoprotein intermediate of the Ca2+-dependent ATPase of sarcoplasmic reticulum was also increased by these ions to an extent that is sufficient to account for the stimulation of calcium transport and Ca2+-dependent ATPase activity. The order of effectiveness of monovalent cations tested at saturating concentrations in increasing rate of phosphoprotein decomposition is: K+, Na+ greater than Rb+, NH4+ greater than Cs+ greater than Li+, choline+, Tris+.
单价阳离子可刺激兔骨骼肌肌浆网的钙转运速率以及Ca²⁺依赖性ATP水解。这些离子还会使肌浆网Ca²⁺依赖性ATP酶的磷蛋白中间体分解速率增加，增加程度足以解释对钙转运和Ca²⁺依赖性ATP酶活性的刺激作用。在饱和浓度下测试的单价阳离子增加磷蛋白分解速率的有效性顺序为：K⁺、Na⁺＞Rb⁺、NH₄⁺＞Cs⁺＞Li⁺、胆碱⁺、Tris⁺。
