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5-羟色胺和瑞扎普明诱发的蠕动：假定的5-羟色胺4受体激活的证据。

Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation.

作者信息

Craig D A, Clarke D E

机构信息

Institute of Pharmacology, Syntex Research, Palo Alto, CA 94304.

出版信息

Br J Pharmacol. 1991 Mar;102(3):563-4. doi: 10.1111/j.1476-5381.1991.tb12211.x.

DOI:10.1111/j.1476-5381.1991.tb12211.x
PMID:1364818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917936/
Abstract

The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205-930 (3 microM), but not ondansetron (5 microM). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.

摘要

研究了5-羟色胺和瑞扎普明对豚鼠离体回肠诱发的蠕动反射的影响。两种药物均能在阈下腔内压力（阈值的50%）时诱发该反射，并被ICS 205-930（3微摩尔）阻断，但不被昂丹司琼（5微摩尔）阻断。这一新颖的发现强烈表明，瑞扎普明的促动力作用和5-羟色胺的肠道动力刺激作用是通过对假定的5-HT4受体的激动作用介导的。

相似文献

1
Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation.5-羟色胺和瑞扎普明诱发的蠕动：假定的5-羟色胺4受体激活的证据。
Br J Pharmacol. 1991 Mar;102(3):563-4. doi: 10.1111/j.1476-5381.1991.tb12211.x.
2
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本文引用的文献

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Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex.关于5-羟色胺对蠕动反射作用的观察
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Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine receptor.豚鼠回肠中一种与5-羟色胺受体性质相似的5-羟色胺神经元受体的药理学特性
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