Craig D A, Clarke D E
Institute of Pharmacology, Syntex Research, Palo Alto, CA 94304.
Br J Pharmacol. 1991 Mar;102(3):563-4. doi: 10.1111/j.1476-5381.1991.tb12211.x.
The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205-930 (3 microM), but not ondansetron (5 microM). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.
研究了5-羟色胺和瑞扎普明对豚鼠离体回肠诱发的蠕动反射的影响。两种药物均能在阈下腔内压力(阈值的50%)时诱发该反射,并被ICS 205-930(3微摩尔)阻断,但不被昂丹司琼(5微摩尔)阻断。这一新颖的发现强烈表明,瑞扎普明的促动力作用和5-羟色胺的肠道动力刺激作用是通过对假定的5-HT4受体的激动作用介导的。