2-羟基亚氨基甲基-N-甲基吡啶甲磺酸盐与阿托品治疗重度有机磷中毒
2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning.
作者信息
DAVIES D R, GREEN A L, WILLEY G L
出版信息
Br J Pharmacol Chemother. 1959 Mar;14(1):5-8. doi: 10.1111/j.1476-5381.1959.tb00920.x.
Abstract
The soluble methanesulphonate of the oxime 2-hydroxyiminomethyl-N-methylpyridinium (P2S) has been used to treat animals poisoned with sarin or ethyl pyrophosphate. The effect of the size of the dose, and its time of administration in relation to poisoning, have been examined. This oxime is very efficient in conjunction with atropine when given either before or after poisoning. About 30 mg./kg. seems to be the optimum therapeutic dose of the methanesulphonate. The significance of this optimum is discussed in relation to the treatment of accidental poisoning by organophosphate insecticides in man.
摘要
肟2-羟基亚胺甲基-N-甲基吡啶鎓的可溶性甲磺酸盐（P2S）已被用于治疗被沙林或焦磷酸乙酯中毒的动物。研究了剂量大小及其给药时间与中毒的关系。这种肟在中毒前后与阿托品联合使用时非常有效。甲磺酸盐的最佳治疗剂量似乎约为30毫克/千克。结合人体有机磷杀虫剂意外中毒的治疗讨论了这一最佳剂量的意义。
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