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肟类化合物与阿托品用于沙林中毒治疗

Oximes and atropine in sarin poisoning.

作者信息

ASKEW B M

出版信息

Br J Pharmacol Chemother. 1957 Sep;12(3):340-3. doi: 10.1111/j.1476-5381.1957.tb00145.x.

DOI:10.1111/j.1476-5381.1957.tb00145.x
PMID:13460241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1509683/
Abstract

Three oximes, monoisonitrosoacetone (MINA), pyridine-2-aldoxime methiodide (PAM) and diacetylmonoxime (DAM), have been examined in combination with atropine as antidotes in sarin poisoning. When treatment was administered 15 min. before sarin, atropine enhanced the protective effect of MINA and DAM 2 to 3 times and of PAM 9 to 10 times in mice and rats. In mice, rats, and guinea-pigs, atropine increased by no more than 2 times the protective effect of all three oximes when given 30 sec. after sarin. Atropine given to monkeys 1 min. after sarin raised the LD50 approximately 3 times. When given in conjunction with MINA or DAM, the LD50 of sarin was raised 7 to 14 times.

摘要

已对三种肟类化合物，即单异亚硝基丙酮（MINA）、吡啶 - 2 - 醛肟甲碘化物（PAM）和二乙酰一肟（DAM）与阿托品联合作为沙林中毒的解毒剂进行了研究。当在沙林中毒前15分钟进行治疗时，在小鼠和大鼠中，阿托品使MINA和DAM的保护作用增强2至3倍，使PAM的保护作用增强9至10倍。在小鼠、大鼠和豚鼠中，沙林中毒后30秒给予阿托品时，其使所有三种肟类化合物的保护作用增强不超过2倍。沙林中毒后1分钟给猴子注射阿托品，使半数致死剂量（LD50）提高了约3倍。当与MINA或DAM联合使用时，沙林的LD50提高了7至14倍。

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