晶体学在抗病毒药物设计中的应用。
Application of crystallography to the design of antiviral agents.
作者信息
Rossmann M G, McKinlay M A
机构信息
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.
出版信息
Infect Agents Dis. 1992 Feb;1(1):3-10.
PMID:1365526
Abstract
A historical review of x-ray crystallography introduces basic concepts and describes the potential of this science to the rational design of antiviral agents. Following a brief introduction to the study of antiviral compounds that inhibit early stages of rhino- and enteroviral infections, the impact of structural studies on rational drug design is discussed in relation to known viral structures.
摘要
X射线晶体学的历史回顾介绍了基本概念，并描述了这门科学在合理设计抗病毒药物方面的潜力。在简要介绍了抑制鼻病毒和肠道病毒感染早期阶段的抗病毒化合物的研究之后，结合已知的病毒结构讨论了结构研究对合理药物设计的影响。
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