Verazin G T, Warneke J A, Driscoll D L, Karakousis C, Petrelli N J, Takita H
Department of Surgical Oncology, New York State Department of Health, Rosewell Park Cancer Institute, Buffalo 14263.
Arch Surg. 1992 Dec;127(12):1407-11. doi: 10.1001/archsurg.1992.01420120041007.
From 1970 through 1986, 78 patients underwent 162 thoracotomies for removal of lung metastases from soft-tissue sarcomas. A multivariate analysis showed that the presence of a local recurrence, an incomplete pulmonary resection, and a shorter disease-free interval were poor prognostic factors. Patients who underwent multiple thoracotomies survived longer from the time of initial thoracotomy. The histologic type of sarcoma and the number of metastases resected showed no statistical significance. The median survival of the 61 patients who had a complete resection was 21 months. Patients with five or fewer metastases resected had an overall 5-year survival of 22% compared with 21% for patients who had six or more metastases resected. However, patients with five or fewer metastases showed a trend toward a higher 10-year disease-free survival. A complete resection of pulmonary metastases from soft-tissue sarcoma can prolong survival even if multiple metastases are present, although patients with fewer metastases may have a longer disease-free survival.
1970年至1986年期间，78例患者接受了162次开胸手术，以切除软组织肉瘤的肺转移灶。多因素分析显示，存在局部复发、肺切除不完全以及无病间期较短是预后不良的因素。接受多次开胸手术的患者从初次开胸手术时起存活时间更长。肉瘤的组织学类型和切除的转移灶数量无统计学意义。61例接受了完整切除的患者的中位生存期为21个月。切除转移灶为5个或更少的患者总体5年生存率为22%，而切除转移灶为6个或更多的患者为21%。然而，转移灶为5个或更少的患者10年无病生存率有升高趋势。软组织肉瘤肺转移灶的完整切除即使存在多个转移灶也可延长生存期，尽管转移灶较少的患者可能无病生存期更长。
