氨基肉碱及相关化合物作为肉碱转移酶抑制剂：生理意义
Aminocarnitine and related compounds as inhibitors of carnitine transferases: physiologic implications.
出版信息
Nutr Rev. 1990 Jun;48(6):258-60. doi: 10.1111/j.1753-4887.1990.tb02952.x.
Abstract
beta-Aminocarnitine and its N-acetyl and N-palmitoyl amides were examined as inhibitors of carnitine acetyltransferase, carnitine palmitoyltransferase, and of fatty-acid oxidation in whole animals, tissues, and hepatic microsomal systems. Results were consistent with subsequent findings that aminocarnitine and palmitoylcarnitine have significant antiketogenic and hypoglycemic effects in experimental animals.
摘要
对β-氨基肉碱及其N-乙酰基和N-棕榈酰酰胺作为肉碱乙酰转移酶、肉碱棕榈酰转移酶的抑制剂以及在完整动物、组织和肝微粒体系统中脂肪酸氧化的抑制剂进行了研究。结果与随后的发现一致，即氨基肉碱和棕榈酰肉碱在实验动物中具有显著的抗生酮和降血糖作用。
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