[Studies of susceptibility to antibiotics in strains of E. coli isolated from urine in the years 1986-1990].

From 1986 to 1990 research was conducted on E. coli strains isolated from patients with clinical symptoms of urinary tract infection. The paper-disk-plate technique was applied to determine their susceptibility to ampicillin, carbenicillin, azlocillin, cefamandole, cefotaxime, ceftriaxone, ceftazidime, cefoperazone, amikacin, netilmicin, gentamycin, vibramycin, and colistin. According to the authors' results the efficacy of ampicillin against the examined strains is as low as 3.4%. Aminoglycosides were traditionally recommended in therapy of urinary tract infections. Our research proves amikacin and netilmicin to be more effective against E. coli than gentamycin. The third-generation cephalosporins are recommended as alternative to aminoglycosides, especially since they are proved to be non-nephrotoxic. According to the results of the authors' research ceftazidime, cefotaxime and particularly ceftriaxone show the highest activity against the used strains of E. coli.