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[外科科室尿路感染分离出的肠杆菌科细菌的氨基糖苷类耐药性]

[Aminoglycoside resistance of enterobacteria isolated from urinary infections in surgical departments].

作者信息

Muntean Delia, Licker Monica, Berceanu-Văduva Delia, Crăciunescu Mihaela, Hogea Elena, Popa Mihaela, Adămut Marcela, Rădulescu Matilda, Moldovan Roxana

机构信息

Universitatea de Medicină şi Farmacie Victor Babe, Timişoara Disciplina de Microbiologie.

出版信息

Bacteriol Virusol Parazitol Epidemiol. 2008 Apr-Jun;53(2):99-102.

Abstract

The aim of the study was to determine the aminoglycosides resistance of Enterobacteriaceae strains isolated from urocultures. Identification of the germs was performed by the API system (BioMerieux) and susceptibility tests was performed by disk-diffusion test (CLSI standards) and with API strips. For detecting the resistance to aminoglycosides we used gentamicin, tobramycin, netilmicin and amikacin. From 2500 urine samples we isolated 673 microbial strains, from which 531 were Enterobacteriaceae, especially E. coli, 57.62% and Klebsiella pneumoniae pneumoniae, 27.68% strains. We observed natural maintained sensibility to aminoglycosides at 55.17% from all the strains we have studied The high prevalence of aminoglycosides resistance of Enterobacteriaceae strains is explained by prolonged antibiotic therapy of patients with invasive diagnostic and therapeutic procedures. A rational policy in prescribing antibiotics in this department is therefore mandatory.

摘要

本研究的目的是确定从尿培养物中分离出的肠杆菌科菌株对氨基糖苷类药物的耐药性。通过API系统(生物梅里埃公司)对细菌进行鉴定,并通过纸片扩散法(CLSI标准)和API试条进行药敏试验。为检测对氨基糖苷类药物的耐药性,我们使用了庆大霉素、妥布霉素、奈替米星和阿米卡星。从2500份尿液样本中,我们分离出673株微生物菌株,其中531株为肠杆菌科,尤其是大肠杆菌,占57.62%,肺炎克雷伯菌占27.68%。我们观察到,在我们研究的所有菌株中,对氨基糖苷类药物天然保持敏感的占55.17%。肠杆菌科菌株对氨基糖苷类药物耐药性的高流行率是由侵入性诊断和治疗程序患者的长期抗生素治疗所解释的。因此,该科室制定合理的抗生素处方政策是必不可少的。

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