Ruiz J, Gabilondo A M, Meana J J, García-Sevilla J A
Department of Pharmacology, University of the Basque Country, Leioa, Bizkaia.
Psychopharmacology (Berl). 1992;109(4):410-4. doi: 10.1007/BF02247716.
The specific binding of the D2-dopamine receptor antagonist radioligand [3H] raclopride was quantitated in the postmortem caudate and frontal cortex from schizophrenic suicide victims and control subjects. In schizophrenic suicides the density of binding sites (Bmax) was higher (40%, P < 0.05) in the caudate, whereas it did not change in the cortex as compared to those in controls. The apparent dissociation constants (KD) were also found increased both in caudate (24%) and cortex (75%) from schizophrenics, but these apparent decreases in receptor affinity did not reach statistical significance. The mean Bmax value in drug-free schizophrenic suicides (n = 3) did not differ from the Bmax value in neuroleptic drug-treated schizophrenics (n = 7) but it was found increased in respect to control subjects (n = 9). No differences in [3H] raclopride binding were observed between non-schizophrenic suicide victims (n = 4) and matched controls (n = 4), suggesting that the modifications of D2-dopamine receptors in schizophrenia are not related to suicide.
在精神分裂症自杀受害者和对照受试者的尸检尾状核和额叶皮质中，对D2 - 多巴胺受体拮抗剂放射性配体[3H]雷氯必利的特异性结合进行了定量分析。在精神分裂症自杀者中，尾状核中结合位点的密度（Bmax）更高（40%，P < 0.05），而与对照组相比，皮质中的结合位点密度没有变化。还发现精神分裂症患者尾状核（24%）和皮质（75%）中的表观解离常数（KD）均增加，但这些受体亲和力的表观降低未达到统计学显著性。未服用药物的精神分裂症自杀者（n = 3）的平均Bmax值与接受抗精神病药物治疗的精神分裂症患者（n = 7）的Bmax值无差异，但相对于对照受试者（n = 9）有所增加。在非精神分裂症自杀受害者（n = 4）和匹配的对照者（n = 4）之间未观察到[3H]雷氯必利结合的差异，这表明精神分裂症中D2 - 多巴胺受体的改变与自杀无关。
