Whitford G M, Pashley D H, Reynolds K E
Am J Physiol. 1977 Jan;232(1):F10-5. doi: 10.1152/ajprenal.1977.232.1.F10.
Urinary bladder absorption of stable and radiofluoride was studied as a function of pH in anesthetized rats to further evaluate the influence of pH gradients on fluoride transport. Buffered pH values and stable fluoride concentrations ranged from 1.85 to 7.90 and from 0.012 to 8.81 mM, respectively. [14c]inulin served as a marker for solute concentration changes due to water migration or dilution. The results indicate that bladder fluoride absorption is inversely related to pH over the 1.85-5.50 range. Mean, 15-min radiofluoride absorption values of 70% at pH 1,85, 37% at pH 3.95, and 5% at pH 5.50 WERE OBSERVED. These fractional absorption values were not significantly influenced by carrier fluoride concentration, the buffers used, or the presence of urine. Above pH 5.50, pH-independent absorption occurs to a slight extent. The results are consistent with a first-order absorptive process which occurs by the nonionic diffusion of hydrogen fluoride.
在麻醉大鼠中研究了稳定氟化物和放射性氟化物的膀胱吸收与pH的关系，以进一步评估pH梯度对氟化物转运的影响。缓冲后的pH值范围为1.85至7.90，稳定氟化物浓度范围为0.012至8.81 mM。[14C]菊粉用作因水迁移或稀释导致溶质浓度变化的标志物。结果表明，在1.85 - 5.50范围内，膀胱氟化物吸收与pH呈负相关。观察到在pH 1.85时，15分钟的放射性氟化物平均吸收值为70%，在pH 3.95时为37%，在pH 5.50时为5%。这些分数吸收值不受载体氟化物浓度、所用缓冲液或尿液存在的显著影响。在pH 5.50以上，会发生轻微的与pH无关的吸收。结果与通过氟化氢的非离子扩散发生的一级吸收过程一致。
