• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

通过仓鼠颊囊吸收氟化物:一个依赖于pH值的过程。

Fluoride absorption through the hamster cheek pouch: a pH-dependent event.

作者信息

Whitford G M, Callan R S, Wang H S

出版信息

J Appl Toxicol. 1982 Dec;2(6):303-6. doi: 10.1002/jat.2550020608.

DOI:10.1002/jat.2550020608
PMID:7185910
Abstract

The fractional absorptions of fluoride, 3H2O, 125I and 14C-DMO from the hamster cheek pouch were determined as functions of solution pH. When the pH was less than 5, fluoride absorption rate was inversely related to pH. The absorption rates of the other substances were not influenced by pH. The fractional absorptions of fluoride and 3H2O were independent of fluoride concentrations over the range 1-53 mM. The data indicate that the absorption of fluoride through this keratinized epithelium occurs mainly by the diffusion of non-ionic HF.

摘要

测定了氟化物、3H2O、125I和14C - DMO从小仓鼠颊囊的分数吸收作为溶液pH值的函数。当pH值小于5时,氟化物吸收速率与pH值呈负相关。其他物质的吸收速率不受pH值影响。氟化物和3H2O的分数吸收在1 - 53 mM范围内与氟化物浓度无关。数据表明,氟化物通过这种角化上皮的吸收主要通过非离子型HF的扩散发生。

相似文献

1
Fluoride absorption through the hamster cheek pouch: a pH-dependent event.通过仓鼠颊囊吸收氟化物:一个依赖于pH值的过程。
J Appl Toxicol. 1982 Dec;2(6):303-6. doi: 10.1002/jat.2550020608.
2
Studies on drug absorption from oral cavity: physicochemical factors affecting absorption from hamster cheek pouch.口腔药物吸收研究:影响仓鼠颊囊吸收的物理化学因素。
J Pharmacobiodyn. 1986 Mar;9(3):287-96. doi: 10.1248/bpb1978.9.287.
3
Carrier-mediated absorption of salicylic acid from hamster cheek pouch mucosa.载体介导的水杨酸从仓鼠颊囊黏膜的吸收。
J Pharm Sci. 1999 Jan;88(1):142-6. doi: 10.1021/js970412e.
4
Studies on drug absorption from oral cavity. II. Influence of the unstirred water layer on absorption from hamster cheek pouch in vitro and in vivo.口腔药物吸收的研究。II. 体外和体内未搅动水层对仓鼠颊囊吸收的影响。
J Pharmacobiodyn. 1987 Apr;10(4):180-7. doi: 10.1248/bpb1978.10.180.
5
Buccal absorption. III. Simultaneous diffusion and metabolism of an aminopeptidase substrate in the hamster cheek pouch.
Pharm Res. 1989 Nov;6(11):966-70. doi: 10.1023/a:1015949614437.
6
Effects of chlorhexidine on the structure and permeability of hamster cheek pouch mucosa.
J Periodontol. 1984 Oct;55(10):608-14. doi: 10.1902/jop.1984.55.10.608.
7
Application of propranolol to the keratinized oral mucosa: avoidance of first-pass elimination and the use of 1-dodecylazacycloheptan-2-one (Azone) as an absorption enhancer of bioadhesive film-dosage form.普萘洛尔在角化口腔黏膜的应用:避免首过消除及使用1-十二烷基氮杂环庚烷-2-酮(氮酮)作为生物黏附膜剂型的吸收促进剂。
J Pharmacobiodyn. 1988 Dec;11(12):824-32. doi: 10.1248/bpb1978.11.824.
8
Effect of chlorhexidine on the hamster cheek pouch. Microcirculation and penetration studies.洗必泰对仓鼠颊囊的影响。微循环与渗透研究。
J Periodontol. 1977 Jul;48(7):421-4. doi: 10.1902/jop.1977.48.7.421.
9
[Vascular reflex in microcirculation of hamster cheek pouch model].[仓鼠颊囊模型微循环中的血管反射]
Kanagawa Shigaku. 1990 Dec;25(3):284-91.
10
Permeation of several drugs through keratinized epithelial-free membrane of hamster cheek pouch.几种药物透过仓鼠颊囊无角化上皮膜的渗透作用。
Int J Pharm. 1999 Jan 15;177(1):7-14. doi: 10.1016/s0378-5173(98)00329-9.

引用本文的文献

1
The acid test of fluoride: how pH modulates toxicity.氟化物的酸试验:pH 值如何调节毒性。
PLoS One. 2010 May 28;5(5):e10895. doi: 10.1371/journal.pone.0010895.
2
Effects of plasma fluoride and dietary calcium concentrations on GI absorption and secretion of fluoride in the rat.血浆氟化物和膳食钙浓度对大鼠胃肠道氟吸收与分泌的影响。
Calcif Tissue Int. 1994 May;54(5):421-5. doi: 10.1007/BF00305530.
3
Fluoride absorption: the influence of gastric acidity.氟吸收:胃酸的影响。
Calcif Tissue Int. 1984 May;36(3):302-7. doi: 10.1007/BF02405334.