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What is the mechanism of the irreversible inhibition of phenylalanine hydroxylase by p-chlorophenylalanine?

作者信息

Brase D A, Loh H H

出版信息

Proc West Pharmacol Soc. 1976;19:172-6.

PMID:136660
Abstract
摘要

相似文献

1
What is the mechanism of the irreversible inhibition of phenylalanine hydroxylase by p-chlorophenylalanine?
Proc West Pharmacol Soc. 1976;19:172-6.
2
The mechanism of the irreversible inhibition ofrat liver phenylalanine hydroxylase due to treatment with p-chlorophenylalanine. The lack of effect on turnover of phenylalanine hydroxylase.
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3
Mechanism of inactivation of phenylalanine hydroxylase by p-chlorophenylalanine in hepatome cells in culture. Two possible models.
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Mechanism of irreversible inactivation of phenylalanine-4- and tryptophan-5-hydroxylases by [4-36Cl, 2-14C]p-chlorophenylalanine: a revision.[4-³⁶Cl, 2-¹⁴C]对氯苯丙氨酸对苯丙氨酸-4-羟化酶和色氨酸-5-羟化酶的不可逆失活机制：一项修正
Neurochem Res. 1982 Jan;7(1):13-26. doi: 10.1007/BF00965065.
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Molecular basis of inhibition of monooxygenases by p-halophenylalanines.对卤苯丙氨酸对单加氧酶抑制作用的分子基础
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Inhibition of phenylalanine hydroxylase by p-chlorophenylalanine; dependence on cofactor structure.对氯苯丙氨酸对苯丙氨酸羟化酶的抑制作用；对辅因子结构的依赖性。
Biochem Biophys Res Commun. 1974 Nov 6;61(1):360-6. doi: 10.1016/0006-291x(74)90575-0.
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Influence of ethanol on the effects of DL-p-chlorophenylalanine on biogenic amines of rat brain.乙醇对DL-对氯苯丙氨酸影响大鼠脑生物胺的作用
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In vivo inhibition of rat liver phenylalanine hydroxylase by p-chlorophenylalanine and Esculin. Experimental model of phenylketonuria.对氯苯丙氨酸和七叶苷对大鼠肝脏苯丙氨酸羟化酶的体内抑制作用。苯丙酮尿症的实验模型。
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P-chlorophenylalanine does not inhibit production of recombinant human phenylalanine hydroxylase in NIH3T3 cells or E. coli.
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10
In vitro effects of L-and D-parachlorophenylalanine on rat liver phenylalanine hydroxylase.
Biochimie. 1980;62(2-3):185-6. doi: 10.1016/s0300-9084(80)80195-7.

引用本文的文献

1
Mechanism of irreversible inactivation of phenylalanine-4- and tryptophan-5-hydroxylases by [4-36Cl, 2-14C]p-chlorophenylalanine: a revision.[4-³⁶Cl, 2-¹⁴C]对氯苯丙氨酸对苯丙氨酸-4-羟化酶和色氨酸-5-羟化酶的不可逆失活机制：一项修正
Neurochem Res. 1982 Jan;7(1):13-26. doi: 10.1007/BF00965065.
2
Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats.中枢酪胺可预防单侧肾切除并用醋酸脱氧皮质酮-生理盐水处理的大鼠发生高血压。
Experientia. 1977 Nov 15;33(11):1430-1. doi: 10.1007/BF01918786.
3
d-Tyrosine prevents hypertension in DOCA-saline treated uninephrectomised rats.
d-酪氨酸可预防去氧皮质酮-生理盐水处理的单侧肾切除大鼠的高血压。
Pflugers Arch. 1979 Apr 30;379(3):245-50. doi: 10.1007/BF00581428.