中枢酪胺可预防单侧肾切除并用醋酸脱氧皮质酮-生理盐水处理的大鼠发生高血压。
Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats.
作者信息
Shalita B, Dikstein S
出版信息
Experientia. 1977 Nov 15;33(11):1430-1. doi: 10.1007/BF01918786.
PMID:923698
Abstract
Prevention of high blood pressure in uninephrectomized, DOCA-saline treated rats was observed after treatment with central tyramine precursors. We suggest that the high blood pressure is either due to relative lack of tyrosine, which might be caused by the hyperactivity of tyrosine hydroxylase, or to hypoactivity of the decarboxylase: in both cases the result is diminished tyramine synthesis.
摘要
在用中枢酪胺前体治疗后，观察到单侧肾切除并用去氧皮质酮-盐水处理的大鼠的高血压得到了预防。我们认为，高血压要么是由于酪氨酸相对缺乏（这可能是由酪氨酸羟化酶的过度活性引起的），要么是由于脱羧酶活性低下：在这两种情况下，结果都是酪胺合成减少。
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