Malick J B, Barnett A
Pharmacol Biochem Behav. 1976 Jul;5(1):55-61. doi: 10.1016/0091-3057(76)90288-4.
Male mice that became aggressive following four weeks of social isolation were treated with seven known serotonin receptor antagonists. All of the antiserotonergic drugs selectively antagonized the fighting behavior of the isolated mice; the antiaggressive activity was selective since, at antifighting doses, none of the drugs either significantly altered spontaneous motor activity or impaired inclined-screen performance. Antagonism of 5-HTP-induced head-twitch was used as an in vivo measure of antiserotonergic activity and a statistically significant correlation existed between potency as an antiserotonergic and potency as an antiaggressive. PCPA, a serotonin depletor, also significantly antagonized isolation-induced aggression for at least 24 hr postdrug administration. The interrelationship between cholinergic and serotonergic mechanisms in the mediation of isolation aggression was investigated. The involvement of serotonergic systems in isolation-induced aggression is discussed.
在经历四周社会隔离后变得具有攻击性的雄性小鼠，接受了七种已知的血清素受体拮抗剂治疗。所有抗血清素能药物都选择性地拮抗了隔离小鼠的战斗行为；这种抗攻击活性具有选择性，因为在抗战斗剂量下，没有一种药物会显著改变自发运动活动或损害倾斜屏幕表现。5-羟色胺酸（5-HTP）诱导的头部抽搐拮抗作用被用作抗血清素能活性的体内测量指标，抗血清素能效力与抗攻击效力之间存在统计学上的显著相关性。对氯苯丙氨酸（PCPA），一种血清素耗竭剂，在给药后至少24小时内也显著拮抗了隔离诱导的攻击行为。研究了胆碱能和血清素能机制在介导隔离攻击中的相互关系。讨论了血清素能系统在隔离诱导攻击中的作用。
