Schügerl K
Institut für Technische Chemie, Universität Hannover, F.R.G.
J Biotechnol. 1990 Mar;13(4):251-6. doi: 10.1016/0168-1656(90)90073-k.
Following a consideration of the prerequisites for reactor comparison and the fundamental differences between stirred tank and airlift tower loop reactors, their performances are compared for the production of secondary metabolites: penicillin V by Penicillium chrysogenum, cephalosporin C by Cephalosporium acremonium, and tetracycline by Streptomyces aureofaciens. In stirred tank reactors, cell mass concentrations, volumetric productivities, and specific power inputs are higher than in airlift tower loop reactors. In the latter, efficiencies of oxygen transfer are higher, and specific productivities with regard to power input, substrate and oxygen consumptions, and yield coefficients of product formation with regard to substrate and oxygen consumptions are considerably higher than in stirred tank reactors. The prerequisites for improved performance are discussed.
在考虑了反应器比较的前提条件以及搅拌釜式反应器和气升式塔式环流反应器之间的根本差异之后，对它们在生产次生代谢产物方面的性能进行了比较：产黄青霉生产青霉素V、顶头孢霉生产头孢菌素C以及金色链霉菌生产四环素。在搅拌釜式反应器中，细胞质量浓度、体积产率和比功率输入均高于气升式塔式环流反应器。在后者中，氧传递效率更高，并且在功率输入、底物和氧气消耗方面的比产率以及在底物和氧气消耗方面产物形成的产率系数均显著高于搅拌釜式反应器。文中还讨论了提高性能的前提条件。
