Renneberg R, Trott-Kriegeskorte G, Lietz M, Jäger V, Pawlowa M, Kaiser G, Wollenberger U, Schubert F, Wagner R, Schmid R D
Zentralinstitut für Molekularbiologie, Berlin-Buch, F.R.G.
J Biotechnol. 1991 Nov;21(1-2):173-85. doi: 10.1016/0168-1656(91)90269-2.
Enzyme sensors for glucose, lactate and glutamine were connected via flow-injection analysis (FIA) devices to two different bioprocesses. They were used for on-line process control of perfused bioreactor systems containing mammalian cell lines producing a monoclonal antibody and recombinant interleukin-2. The biosensor system gives direct access to important process data which can be used as control parameters for long term cell cultivation systems.
用于葡萄糖、乳酸盐和谷氨酰胺的酶传感器通过流动注射分析（FIA）设备连接到两个不同的生物过程。它们被用于对含有产生单克隆抗体的哺乳动物细胞系和重组白细胞介素-2的灌注生物反应器系统进行在线过程控制。该生物传感器系统可直接获取重要的过程数据，这些数据可用作长期细胞培养系统的控制参数。
