Albright A Leland
Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
J Child Neurol. 2003 Sep;18 Suppl 1:S67-78. doi: 10.1177/0883073803018001S0801.
For children whose spasticity and movement disorders are inadequately treated by oral medications and botulinum toxins, neurosurgical procedures are now available to effectively treat spasticity, tremor, and many cases of dystonia. Spastic diplegia can be treated with selective lumbar rhizotomies, which significantly decrease spasticity, increase range of motion, and improve Gross Motor Function Measure scores. Children with spastic quadriparesis and those with secondary dystonia can be treated with intrathecal baclofen, which diminishes both spasticity and dystonia and is associated with improved function and quality of life. Children with primary dystonia and those with tremor can be treated with deep brain stimulation of the internal globus pallidus and thalamus, respectively. Some children with chorea respond to deep brain stimulation. There are no effective neurosurgical treatments for athetosis or ataxia. The effectiveness of neurosurgical treatments of pediatric movement disorders has increased significantly in the past 15 years.
对于那些口服药物和肉毒杆菌毒素无法充分治疗痉挛和运动障碍的儿童,现在有神经外科手术可有效治疗痉挛、震颤以及许多肌张力障碍病例。痉挛性双侧瘫可通过选择性腰神经根切断术进行治疗,该手术能显著降低痉挛程度,增加活动范围,并提高粗大运动功能测量评分。痉挛性四肢瘫患儿和继发性肌张力障碍患儿可采用鞘内注射巴氯芬治疗,这能减轻痉挛和肌张力障碍,并改善功能和生活质量。原发性肌张力障碍患儿和震颤患儿可分别通过对内侧苍白球和丘脑进行深部脑刺激来治疗。一些舞蹈症患儿对深部脑刺激有反应。目前尚无针对手足徐动症或共济失调的有效神经外科治疗方法。在过去15年中,小儿运动障碍的神经外科治疗效果有了显著提高。