Bögre László, Okrész László, Henriques Rossana, Anthony Richard G
School of Biological Sciences, Royal Holloway, University of London, Egham TW20 0EX, UK .
Trends Plant Sci. 2003 Sep;8(9):424-31. doi: 10.1016/S1360-1385(03)00188-2.
Lipid-derived signals are central to regulating a multitude of cellular processes but, in plants, little is known of the downstream signalling pathways. The Arabidopsis 3-phosphoinositide-dependent protein kinase (PDK1) could couple lipid signals to the activation of several protein kinases of the so-called AGC kinase family. The Arabidopsis AGC kinases contain sequence motives required for the docking of PDK1 and phosphorylation of their activation loop in the kinase catalytic domain. It is becoming evident that specific members of the AGC kinases are implicated in key growth signalling pathways. For example, Arabidopsis p70(S6K) might be a nodal point able to integrate hormonal and developmental signals with nutritional inputs, together with the Arabidopsis Target of Rapamycin (TOR) protein.
脂质衍生信号在调节众多细胞过程中起着核心作用，但在植物中，对其下游信号通路却知之甚少。拟南芥3-磷酸肌醇依赖性蛋白激酶（PDK1）可将脂质信号与所谓AGC激酶家族的几种蛋白激酶的激活相偶联。拟南芥AGC激酶在激酶催化结构域中含有PDK1对接及其激活环磷酸化所需的序列基序。越来越明显的是，AGC激酶的特定成员参与关键的生长信号通路。例如，拟南芥p70（S6K）可能是一个节点，能够将激素和发育信号与营养输入整合在一起，与拟南芥雷帕霉素靶蛋白（TOR）共同发挥作用。
