Hwang Bang Yeon, Lee Jeong Hyung, Nam Jeong Bum, Hong Young Soo, Lee Jung Joon
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yuseong, Daejeon 305-600, South Korea.
Phytochemistry. 2003 Oct;64(3):765-71. doi: 10.1016/s0031-9422(03)00391-1.
The sesquineolignans, saucerneol D and saucerneol E were isolated from the roots of Saururus chinensis together with four known lignans, manassantin A, manassantin B, (-)-saucerneol methyl ether, and (+)-saucernetin. Structure elucidation was based on the analysis of spectroscopic data and anti-inflammatory activity was studied using HeLa cells transfected with NF-kappaB reporter construct. All compounds except for (+)-saucernetin inhibited NF-kappaB dependent reporter gene expression with IC50 values of 2.5-16.9 microM.
从三白草的根部分离出倍半木脂素、三白草新木脂素D和三白草新木脂素E，以及四种已知木脂素，即马兜铃苦素A、马兜铃苦素B、（-）-三白草新木脂素甲醚和（+）-三白草黄素。结构解析基于光谱数据分析，并使用转染了NF-κB报告基因构建体的HeLa细胞研究了抗炎活性。除（+）-三白草黄素外，所有化合物均抑制NF-κB依赖性报告基因表达，IC50值为2.5-16.9 microM。
