来自吕宋番龙眼的齐墩果烷型糖苷。
Oleanolic glycosides from Pometia ridleyi.
作者信息
Voutquenne Laurence, Guinot Pauline, Thoison Odile, Sevenet Thierry, Lavaud Catherine
机构信息
Laboratoire de Pharmacognosie, UMR CNRS 6013, Bât. 18, BP 1039, 51097, Reims Cedex, France.
出版信息
Phytochemistry. 2003 Oct;64(3):781-9. doi: 10.1016/s0031-9422(03)00380-7.
Six triterpenoid saponins were isolated from the stem bark of Pometia ridleyi along with two known saponins, acutoside A and calenduloside C. Their structures were established using one- and two-dimensional NMR and mass spectrometry as 3-O-beta-D-apiofuranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-beta-D-glucopyranosyl-, 3-O-beta-D-apiofuranosyl-(1-->3)-alpha-L-arabinopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-beta-D-glucopyranosyl-, 3-O-beta-D-apiofuranosyl-(1-->3)-beta-D-galactopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-beta-D-glucopyranosyl-, 3-O-alpha-L-arabinopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl-, 3-O-beta-D-galactopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl-, 3-O-beta-D-apiofuranosyl-(1-->3)-beta-D-galactopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl-oleanolic acid. The EtOH and EtOAc extracts of the stem bark showed no cytotoxic activity. At a concentration of 23 microg/ml, the saponin mixture showed haemolytic activity and caused 50% haemolysis of a 10% suspension of sheep erythrocytes.
从菲律宾番龙眼的茎皮中分离出六种三萜皂苷以及两种已知皂苷，即刺五加苷A和金盏花苷C。通过一维和二维核磁共振以及质谱确定它们的结构分别为3 - O - β - D - 芹菜呋喃糖基 - (1→3) - [β - D - 吡喃葡萄糖基 - (1→2)] - β - D - 吡喃葡萄糖基 - 、3 - O - β - D - 芹菜呋喃糖基 - (1→3) - α - L - 阿拉伯吡喃糖基 - (1→3) - [β - D - 吡喃葡萄糖基 - (1→2)] - β - D - 吡喃葡萄糖基 - 、3 - O - β - D - 芹菜呋喃糖基 - (1→3) - β - D - 吡喃半乳糖基 - (1→3) - [β - D - 吡喃葡萄糖基 - (1→2)] - β - D - 吡喃葡萄糖基 - 、3 - O - α - L - 阿拉伯吡喃糖基 - (1→3) - [β - D - 吡喃葡萄糖基 - (1→2)] - α - L - 阿拉伯吡喃糖基 - 、3 - O - β - D - 吡喃半乳糖基 - (1→3) - [β - D - 吡喃葡萄糖基 - (1→2)] - α - L - 阿拉伯吡喃糖基 - 、3 - O - β - D - 芹菜呋喃糖基 - (1→3) - β - D - 吡喃半乳糖基 - (1→3) - [β - D - 吡喃葡萄糖基 - (1→2)] - α - L - 阿拉伯吡喃糖基 - 齐墩果酸。茎皮的乙醇提取物和乙酸乙酯提取物没有细胞毒性活性。在浓度为23微克/毫升时，皂苷混合物表现出溶血活性，导致10%绵羊红细胞悬液发生50%的溶血。
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