Artali Roberto, Barili Pier Luigi, Bombieri Gabriella, Re Paolo Da, Marchini Nicoletta, Meneghetti Fiorella, Valenti Piero
Istituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Viale Abruzzi, 42, I-20131 Milan, Italy.
Farmaco. 2003 Sep;58(9):875-81. doi: 10.1016/S0014-827X(03)00145-9.
The reactions of iodoflavone with 3-methyl-3-hydroxybut-1-yne and 3-methylbut-3-en-2-yne are described and the antimicrobial and cytotoxic activities of the obtained compounds have been tested. The molecular structures of 6-(3-hydroxy-3-methylbut-1-ynyl)-flavone (1a) and 6-(3-methylbut-3-en-1-ynyl) flavone (1b) have been determined by X-ray crystallography. The planar configuration of the two compounds has been attributed to intramolecular hydrogen bond interactions. In 1a, the presence of the hydroxyl group determines a dimeric arrangement of the molecules. In both compounds in the crystal state, molecular stacking has been observed.
描述了碘黄酮与3-甲基-3-羟基丁-1-炔和3-甲基丁-3-烯-2-炔的反应，并测试了所得化合物的抗菌和细胞毒性活性。通过X射线晶体学确定了6-(3-羟基-3-甲基丁-1-炔基)黄酮(1a)和6-(3-甲基丁-3-烯-1-炔基)黄酮(1b)的分子结构。这两种化合物的平面构型归因于分子内氢键相互作用。在1a中，羟基的存在决定了分子的二聚排列。在晶体状态下的两种化合物中，均观察到了分子堆积。
