Heaney Conor J, Campeau Norbert G, Lindell E Paul
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
AJNR Am J Neuroradiol. 2003 Sep;24(8):1615-7.
We describe a case demonstrating reversible MR imaging findings, including diffusion-weighted imaging changes in association with metronidazole (Flagyl) toxicity. The diagnosis of metronidazole toxicity was made clinically and supported by the MR imaging findings. Quantitative apparent diffusion coefficient (ADC) maps demonstrated edema with associated increased ADC values within the dentate nuclei of the cerebellum on initial imaging. Follow-up imaging performed 8 weeks after cessation of metronidazole therapy demonstrated resolution of imaging findings, including diffusion changes.
我们描述了一例显示可逆性磁共振成像（MR）表现的病例，包括与甲硝唑（灭滴灵）毒性相关的扩散加权成像变化。甲硝唑毒性的诊断是临床作出的，并得到了MR成像结果的支持。定量表观扩散系数（ADC）图显示，初始成像时小脑齿状核内存在水肿且ADC值升高。在停止甲硝唑治疗8周后进行的随访成像显示，成像表现包括扩散变化均已消失。
